The 2nd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2008: www.icbbe.org ) will be held from May 16th to 18th, 2008 in Shanghai, China. iCBBE2008 will bring together top researchers from Asian Pacific areas, North America, Europe and around the world to exchange research results and address open issues in all aspects of bioinformatics and biomedical engineering. As we did in iCBBE 2007, All accepted papers in iCBBE 2008 will be published by IEEE, and will be indexed by EI Compendex.